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TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends
Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3′ overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We present evidence suggesting...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Pub. Group
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4235626/ https://ncbi.nlm.nih.gov/pubmed/25399868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6467 |
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