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Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors
Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and carboxymethylation. Lamin A is further processed by proteolysis to remove the farnesyl, but B-type lamins remain permanently farn...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3621746/ https://ncbi.nlm.nih.gov/pubmed/23475125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.24089 |
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