Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells

More than 20 mutations in the gene encoding A-type lamins (LMNA) cause progeria, a rare premature aging disorder. The major pathognomonic hallmarks of progeria cells are seen as nuclear deformations or blebs that are related to the redistribution of A- and B-type lamins within the nuclear lamina. Ho...

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Dades bibliogràfiques
Publicat a:Nucleus
Autors principals: Bercht Pfleghaar, Katrin, Taimen, Pekka, Butin-Israeli, Veronika, Shimi, Takeshi, Langer-Freitag, Sabine, Markaki, Yolanda, Goldman, Anne E, Wehnert, Manfred, Goldman, Robert D
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615727/
https://ncbi.nlm.nih.gov/pubmed/25738644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2015.1004256
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