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Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors

Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and carboxymethylation. Lamin A is further processed by proteolysis to remove the farnesyl, but B-type lamins remain permanently farn...

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Hlavní autoři: Adam, Stephen A., Butin-Israeli, Veronika, Cleland, Megan M., Shimi, Takeshi, Goldman, Robert D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621746/
https://ncbi.nlm.nih.gov/pubmed/23475125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.24089
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