Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

[Image: see text] Through a “tag-and-modify” protein chemical modification strategy, we site-selectively phosphorylated the activation loop of protein kinase p38α. Phosphorylation at natural (180) and unnatural (172) sites created two pure phospho-forms. p38α bearing only a single phosphocysteine (p...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Chooi, K. Phin, Galan, Sébastien R. G., Raj, Ritu, McCullagh, James, Mohammed, Shabaz, Jones, Lyn H., Davis, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235370/
https://ncbi.nlm.nih.gov/pubmed/24393126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4095318
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