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Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

The mitogen-activated protein (MAP) kinases are essential signaling molecules that mediate many cellular effects of growth factors, cytokines, and stress stimuli. Full activation of the MAP kinases requires dual phosphorylation of the Thr and Tyr residues in the TXY motif of the activation loop by M...

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Autori principali: Zhang, Yuan-Yuan, Mei, Zi-Qing, Wu, Jia-Wei, Wang, Zhi-Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258911/
https://ncbi.nlm.nih.gov/pubmed/18669639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801703200
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