Inhibition of Mitogen-activated Protein Kinase Phosphatase 3 Activity by Interdomain Binding

Mitogen-activated protein (MAP) kinase phosphatase 3 (MKP3) is a cytoplasmic dual specificity phosphatase that functions to attenuate signaling via dephosphorylation and subsequent deactivation of its substrate and allosteric regulator, extracellular signal-regulated protein kinase 2 (ERK2). Express...

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Bibliografiske detaljer
Main Authors: Mark, John K., Aubin, Rémy A., Smith, Sophie, Hefford, Mary Alice
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661409/
https://ncbi.nlm.nih.gov/pubmed/18694935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801747200
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