LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Enzyme-mediated damage repair or mitigation, whilst common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenesis and aging. Bacterial LanC enzymes use Dha/Dhb to form carbon-sulfur lin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Lai, Kuan-Yu, Galan, Sébastien R. G., Zeng, Yibo, Zhou, Hina, He, Chang, Raj, Ritu, Riedl, Jitka, Liu, Shi, Chooi, K. Phin, Garg, Neha, Zeng, Min, Jones, Lyn H., Hutchings, Graham J., Mohammed, Shabaz, Nair, Satish K., Chen, Jie, Davis, Benjamin G., van der Donk, Wilfred A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209957/
https://ncbi.nlm.nih.gov/pubmed/33932340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.04.001
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