LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Enzyme-mediated damage repair or mitigation, whilst common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenesis and aging. Bacterial LanC enzymes use Dha/Dhb to form carbon-sulfur lin...

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Publicado no:Cell
Main Authors: Lai, Kuan-Yu, Galan, Sébastien R. G., Zeng, Yibo, Zhou, Hina, He, Chang, Raj, Ritu, Riedl, Jitka, Liu, Shi, Chooi, K. Phin, Garg, Neha, Zeng, Min, Jones, Lyn H., Hutchings, Graham J., Mohammed, Shabaz, Nair, Satish K., Chen, Jie, Davis, Benjamin G., van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209957/
https://ncbi.nlm.nih.gov/pubmed/33932340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.04.001
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