Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors

[Image: see text] We report the design and synthesis of fluorine-containing cyclooxygenase-1 (COX-1)-selective inhibitors to serve as prototypes for the development of a COX-1-targeted imaging agent. Deletion of the SO(2)CH(3) group of rofecoxib switches the compound from a COX-2- to a COX-1-selecti...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Uddin, Md. Jashim, Elleman, Anna V., Ghebreselasie, Kebreab, Daniel, Cristina K., Crews, Brenda C., Nance, Kellie D., Huda, Tamanna, Marnett, Lawrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233350/
https://ncbi.nlm.nih.gov/pubmed/25408841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500344j
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