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Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors
[Image: see text] We report the design and synthesis of fluorine-containing cyclooxygenase-1 (COX-1)-selective inhibitors to serve as prototypes for the development of a COX-1-targeted imaging agent. Deletion of the SO(2)CH(3) group of rofecoxib switches the compound from a COX-2- to a COX-1-selecti...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2014
|
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233350/ https://ncbi.nlm.nih.gov/pubmed/25408841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500344j |
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