Tumor suppressive miR-148a is silenced by CpG island hypermethylation in IDH1 mutant gliomas

PURPOSE: IDH1/2 mutant gliomas harbor a distinct CpG island methylation profile (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor suppressive genes. The potential role of tumor suppressive miRNAs in this process is not understood. EXPERIMENTAL D...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Li, Sichen, Chowdhury, Reshmi, Liu, Fei, Chou, Arthur P., Li, Tie, Mody, Reema R., Lou, Jerry J., Chen, Weidong, Reiss, Jean, Soto, Horacio, Prins, Robert, Liau, Linda M., Mischel, Paul S., Nghiemphu, Phioanh L., Yong, William H., Cloughesy, Timothy F., Lai, Albert
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233178/
https://ncbi.nlm.nih.gov/pubmed/25224277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0234
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