Tumor suppressive miR-148a is silenced by CpG island hypermethylation in IDH1 mutant gliomas

PURPOSE: IDH1/2 mutant gliomas harbor a distinct CpG island methylation profile (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor suppressive genes. The potential role of tumor suppressive miRNAs in this process is not understood. EXPERIMENTAL D...

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Publicado no:Clin Cancer Res
Main Authors: Li, Sichen, Chowdhury, Reshmi, Liu, Fei, Chou, Arthur P., Li, Tie, Mody, Reema R., Lou, Jerry J., Chen, Weidong, Reiss, Jean, Soto, Horacio, Prins, Robert, Liau, Linda M., Mischel, Paul S., Nghiemphu, Phioanh L., Yong, William H., Cloughesy, Timothy F., Lai, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233178/
https://ncbi.nlm.nih.gov/pubmed/25224277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0234
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