SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

PURPOSE: Both IDH1-mutated and wild-type gliomas abundantly display aberrant CpG island hypermethylation. However, the potential role of hypermethylation in promoting gliomas, especially the most aggressive form, glioblastoma (GBM), remains poorly understood. METHODS: We analyzed RRBS-generated meth...

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Publicat a:J Neurooncol
Autors principals: Liu, Fei, Cox, Christopher D., Chowdhury, Reshmi, Dovek, Laura, Nguyen, Huytram, Li, Tie, Li, Sichen, Ozer, Byram, Chou, Arthur, Nguyen, Nhung, Wei, Bowen, Antonios, Joseph, Soto, Horacio, Kornblum, Harley, Liau, Linda, Prins, Robert, Nghiemphu, P. Leia, Yong, William, Cloughesy, Timothy, Lai, Albert
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516751/
https://ncbi.nlm.nih.gov/pubmed/30838489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03126-x
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