SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

PURPOSE: Both IDH1-mutated and wild-type gliomas abundantly display aberrant CpG island hypermethylation. However, the potential role of hypermethylation in promoting gliomas, especially the most aggressive form, glioblastoma (GBM), remains poorly understood. METHODS: We analyzed RRBS-generated meth...

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Pubblicato in:J Neurooncol
Autori principali: Liu, Fei, Cox, Christopher D., Chowdhury, Reshmi, Dovek, Laura, Nguyen, Huytram, Li, Tie, Li, Sichen, Ozer, Byram, Chou, Arthur, Nguyen, Nhung, Wei, Bowen, Antonios, Joseph, Soto, Horacio, Kornblum, Harley, Liau, Linda, Prins, Robert, Nghiemphu, P. Leia, Yong, William, Cloughesy, Timothy, Lai, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516751/
https://ncbi.nlm.nih.gov/pubmed/30838489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03126-x
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