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SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

PURPOSE: Both IDH1-mutated and wild-type gliomas abundantly display aberrant CpG island hypermethylation. However, the potential role of hypermethylation in promoting gliomas, especially the most aggressive form, glioblastoma (GBM), remains poorly understood. METHODS: We analyzed RRBS-generated meth...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Neurooncol
Κύριοι συγγραφείς: Liu, Fei, Cox, Christopher D., Chowdhury, Reshmi, Dovek, Laura, Nguyen, Huytram, Li, Tie, Li, Sichen, Ozer, Byram, Chou, Arthur, Nguyen, Nhung, Wei, Bowen, Antonios, Joseph, Soto, Horacio, Kornblum, Harley, Liau, Linda, Prins, Robert, Nghiemphu, P. Leia, Yong, William, Cloughesy, Timothy, Lai, Albert
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516751/
https://ncbi.nlm.nih.gov/pubmed/30838489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03126-x
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