GENE-41. EPIGENETIC DOWN-REGULATION OF THE METALLOTHIONEIN FAMILY IN ISOCITRATE DEHYDROGENASE (IDH) MUTANT GLIOMAS

BACKGROUND: IDH mutant gliomas demonstrate a CpG island methylator phenotype (G-CIMP) thought to be triggered by oncometabolite D-2HG as a consequence of down-regulation of TET and JHDM. As identified here, G-CIMP includes members of the heavy metal-binding metallothionein 1 (MT1) family involved in...

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Publicado en:Neuro Oncol
Autores principales: Ozer, Byram, Chowdhury, Reshmi, Li, Tie, Bui, Yvonne, Nguyen, Nhung, Yong, William, Liau, Linda, Nghiemphu, Phioanh, Cloughesy, Timothy, Lai, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692108/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.414
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