D-2-Hydroxyglutarate is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-induced MIR148A Promoter Methylation

Mutant isocitrate dehydrogenase (IDH) 1/2 converts α-ketoglutarate (α-KG) to D-2 hydroxyglutarate (D-2-HG), a putative oncometabolite that can inhibit α-KG dependent enzymes, including ten-eleven translocation methylcytosine dioxygenase (TET) DNA demethylases. We recently established that miRNAs are...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Li, Tie, Cox, Christopher D., Ozer, Byram H., Nguyen, Nhung T., Nguyen, HuyTram N., Lai, Thomas J., Li, Sichen, Liu, Fei, Kornblum, Harley I., Liau, Linda M., Nghiemphu, Phioanh L., Cloughesy, Timothy F., Lai, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984679/
https://ncbi.nlm.nih.gov/pubmed/29545476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0367
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