D-2-Hydroxyglutarate is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-induced MIR148A Promoter Methylation

Mutant isocitrate dehydrogenase (IDH) 1/2 converts α-ketoglutarate (α-KG) to D-2 hydroxyglutarate (D-2-HG), a putative oncometabolite that can inhibit α-KG dependent enzymes, including ten-eleven translocation methylcytosine dioxygenase (TET) DNA demethylases. We recently established that miRNAs are...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Res
Huvudupphovsmän: Li, Tie, Cox, Christopher D., Ozer, Byram H., Nguyen, Nhung T., Nguyen, HuyTram N., Lai, Thomas J., Li, Sichen, Liu, Fei, Kornblum, Harley I., Liau, Linda M., Nghiemphu, Phioanh L., Cloughesy, Timothy F., Lai, Albert
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984679/
https://ncbi.nlm.nih.gov/pubmed/29545476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0367
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