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Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies

PURPOSE: To activate and propagate populations of γδT cells expressing polyclonal repertoire of γ and δ TCR chains for adoptive immunotherapy for cancer, which has yet to be achieved. EXPERIMENTAL DESIGN: Clinical-grade artificial antigen presenting cells (aAPC) derived from K562 tumor cells were us...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Deniger, Drew C., Maiti, Sourindra N., Mi, Tiejuan, Switzer, Kirsten C., Ramachandran, Vijaya, Hurton, Lenka V., Ang, Sonny, Olivares, Simon, Rabinovich, Brian A., Huls, Helen, Lee, Dean A., Bast, Robert C., Champlin, Richard E., Cooper, Laurence J.N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233015/
https://ncbi.nlm.nih.gov/pubmed/24833662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3451
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