Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies

PURPOSE: To activate and propagate populations of γδT cells expressing polyclonal repertoire of γ and δ TCR chains for adoptive immunotherapy for cancer, which has yet to be achieved. EXPERIMENTAL DESIGN: Clinical-grade artificial antigen presenting cells (aAPC) derived from K562 tumor cells were us...

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Publicado en:Clin Cancer Res
Autores principales: Deniger, Drew C., Maiti, Sourindra N., Mi, Tiejuan, Switzer, Kirsten C., Ramachandran, Vijaya, Hurton, Lenka V., Ang, Sonny, Olivares, Simon, Rabinovich, Brian A., Huls, Helen, Lee, Dean A., Bast, Robert C., Champlin, Richard E., Cooper, Laurence J.N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233015/
https://ncbi.nlm.nih.gov/pubmed/24833662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3451
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