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The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex
The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We...
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| Pubblicato in: | Biochem J |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Portland Press Ltd.
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232260/ https://ncbi.nlm.nih.gov/pubmed/25186459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140606 |
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