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The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
Rho-family GTPases are activated by the exchange of bound GDP for GTP, a process that is catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of Dbl-family GEFs consists of a Dbl-homology (DH) domain followed almost invariantly by a pleckstrin-homology (PH) domain....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890047/ https://ncbi.nlm.nih.gov/pubmed/17391702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.060 |
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