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The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in C. elegans body wall muscle
Mutation of the C. elegans gene unc-89 results in disorganization of muscle A-bands. unc-89 encodes a giant polypeptide (900 kDa) containing at its N-terminus, a DH followed by a PH domain, which is characteristic of guanine nucleotide exchange factor (GEF) proteins for Rho GTPases. To obtain eviden...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2578821/ https://ncbi.nlm.nih.gov/pubmed/18801371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.08.083 |
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