The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We...

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Bibliografische gegevens
Gepubliceerd in:Biochem J
Hoofdauteurs: Abdul Azeez, Kamal R., Knapp, Stefan, Fernandes, João M. P., Klussmann, Enno, Elkins, Jonathan M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2014
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232260/
https://ncbi.nlm.nih.gov/pubmed/25186459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140606
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