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Enzyme Architecture: Deconstruction of the Enzyme-Activating Phosphodianion Interactions of Orotidine 5′-Monophosphate Decarboxylase

[Image: see text] The mechanism for activation of orotidine 5′-monophosphate decarboxylase (OMPDC) by interactions of side chains from Gln215 and Try217 at a gripper loop and R235, adjacent to this loop, with the phosphodianion of OMP was probed by determining the kinetic parameters k(cat) and K(m)...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Goldman, Lawrence M., Amyes, Tina L., Goryanova, Bogdana, Gerlt, John A., Richard, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227808/
https://ncbi.nlm.nih.gov/pubmed/24958125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505037v
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