Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis

[Image: see text] We report the results of a study of the catalytic role of a network of four interacting amino acid side chains at yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC), by the stepwise replacement of all four side chains. The H-bond, which links the −CH(2)OH side chain of S154 f...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Reyes, Archie C., Plache, David C., Koudelka, Astrid P., Amyes, Tina L., Gerlt, John A., Richard, John P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317530/
https://ncbi.nlm.nih.gov/pubmed/30475611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09609
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