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Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis
[Image: see text] We report the results of a study of the catalytic role of a network of four interacting amino acid side chains at yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC), by the stepwise replacement of all four side chains. The H-bond, which links the −CH(2)OH side chain of S154 f...
Shranjeno v:
| izdano v: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2018
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317530/ https://ncbi.nlm.nih.gov/pubmed/30475611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09609 |
| Oznake: |
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