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Catalysis by Orotidine 5′-Monophosphate Decarboxylase: Effect of 5-Fluoro and 4′-Substituents on the Decarboxylation of Two-Part Substrates()

The syntheses of two novel truncated analogs of the natural substrate orotidine 5′-monophosphate (OMP) for orotidine 5′-monophosphate decarboxylase (OMPDC) with enhanced reactivity towards decarboxylation are reported: 1-(β-D-erythrofuranosyl)-5-fluoroorotic acid (FEO) and 5′-deoxy-5-fluoroorotidine...

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Detalhes bibliográficos
Main Authors: Goryanova, Bogdana, Spong, Krisztina, Amyes, Tina L., Richard, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556479/
https://ncbi.nlm.nih.gov/pubmed/23276261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301650d
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