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Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

To elucidate the mechanism of recognition of double-stranded DNA (dsDNA) by homopyrimidine polyamide ("peptide") nucleic acid (PNA) leading to the strand-displacement, the kinetics of the sequence-specific PNA/DNA binding have been studied. The binding was monitored with time by the gel re...

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Detalhes bibliográficos
Main Authors: Demidov, V V, Yavnilovich, M V, Belotserkovskii, B P, Frank-Kamenetskii, M D, Nielsen, P E
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42273/
https://ncbi.nlm.nih.gov/pubmed/7708697
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