Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

To elucidate the mechanism of recognition of double-stranded DNA (dsDNA) by homopyrimidine polyamide ("peptide") nucleic acid (PNA) leading to the strand-displacement, the kinetics of the sequence-specific PNA/DNA binding have been studied. The binding was monitored with time by the gel re...

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Bibliographic Details
Main Authors: Demidov, V V, Yavnilovich, M V, Belotserkovskii, B P, Frank-Kamenetskii, M D, Nielsen, P E
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC42273/
https://ncbi.nlm.nih.gov/pubmed/7708697
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