DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins
Abstract Single-stranded DNA-binding proteins (SSBs) protect transiently exposed ssDNA, yet how DNA polymerase (DNAp) displaces them during replication remains unclear. Using single-molecule force spectroscopy, dual-color imaging, and molecular dynamics simulations on bacteriophage T7 DNAp and SSB,...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2025-08-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-025-62531-1 |
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