Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

A cornerstone of preclinical cancer research has been the use of clonal cell lines. However, this resource has underperformed in its ability to effectively identify novel therapeutics and evaluate the heterogeneity in a patient's tumor. The patient-derived xenograft (PDX) model retains the hete...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Dobbin, Zachary C., Katre, Ashwini A., Steg, Adam D., Erickson, Britt K., Shah, Monjri M., Alvarez, Ronald D., Conner, Michael G., Schneider, David, Chen, Dongquan, Landen, Charles N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226719/
https://ncbi.nlm.nih.gov/pubmed/25209969
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