Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer

PURPOSE: Endoglin (ENG, CD105) is a membranous protein overexpressed in tumor-associated endothelial cells, chemoresistant populations of ovarian cancer cells, and potentially stem cells. Our objective was to evaluate the effects and mechanisms of targeting endoglin in ovarian cancer. EXPERIMENTAL D...

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Autori principali: Ziebarth, Angela J., Nowsheen, Somaira, Steg, Adam D., Shah, Monjri M., Katre, Ashwini A., Dobbin, Zachary C., Han, Hee-Dong, Lopez-Berestein, Gabriel, Sood, Anil K., Conner, Michael, Yang, Eddy S., Landen, Charles N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537868/
https://ncbi.nlm.nih.gov/pubmed/23147994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1045
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