Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer

The goal of this study was to determine whether combined targeted therapies, specifically those against the Notch, hedgehog and ubiquitin-proteasome pathways, could overcome ovarian cancer chemoresistance. Chemoresistant ovarian cancer cells were exposed to gamma-secretase inhibitors (GSI-I, Compoun...

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Bibliographic Details
Main Authors: Steg, Adam D., Burke, Mata R., Amm, Hope M., Katre, Ashwini A., Dobbin, Zachary C., Jeong, Dae Hoon, Landen, Charles N.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196184/
https://ncbi.nlm.nih.gov/pubmed/25216523
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