Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

A cornerstone of preclinical cancer research has been the use of clonal cell lines. However, this resource has underperformed in its ability to effectively identify novel therapeutics and evaluate the heterogeneity in a patient's tumor. The patient-derived xenograft (PDX) model retains the hete...

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Vydáno v:Oncotarget
Hlavní autoři: Dobbin, Zachary C., Katre, Ashwini A., Steg, Adam D., Erickson, Britt K., Shah, Monjri M., Alvarez, Ronald D., Conner, Michael G., Schneider, David, Chen, Dongquan, Landen, Charles N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226719/
https://ncbi.nlm.nih.gov/pubmed/25209969
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