TARGETING RNA-POLYMERASE I IN BOTH CHEMOSENSITIVE AND CHEMORESISTANT POPULATIONS IN EPITHELIAL OVARIAN CANCER

PURPOSE: A hallmark of neoplasia is increased ribosome biogenesis, and targeting this process with RNA polymerase I (Pol I) inhibitors has shown some efficacy. We examined the contribution and potential targeting of ribosomal machinery in chemotherapy resistant and sensitive models of ovarian cancer...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Cornelison, Robert, Dobbin, Zachary C., Katre, Ashwini A., Jeong, Dae Hoon, Zhang, Yinfeng, Chen, Dongquan, Petrova, Yuliya, Llaneza, Danielle C., Steg, Adam D., Parsons, Laura, Schneider, David A., Landen, Charles N.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668148/
https://ncbi.nlm.nih.gov/pubmed/28778862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0282
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