The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

BACKGROUND: The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here we report the special character of Arctic AD neuropathology in four deceased pat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Kalimo, Hannu, Lalowski, Maciej, Bogdanovic, Nenad, Philipson, Ola, Bird, Thomas D, Nochlin, David, Schellenberg, Gerard D, Brundin, RoseMarie, Olofsson, Tommie, Soliymani, Rabah, Baumann, Marc, Wirths, Oliver, Bayer, Thomas A, Nilsson, Lars NG, Basun, Hans, Lannfelt, Lars, Ingelsson, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226306/
https://ncbi.nlm.nih.gov/pubmed/24252272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-60
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge