The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

BACKGROUND: The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here we report the special character of Arctic AD neuropathology in four deceased pat...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Kalimo, Hannu, Lalowski, Maciej, Bogdanovic, Nenad, Philipson, Ola, Bird, Thomas D, Nochlin, David, Schellenberg, Gerard D, Brundin, RoseMarie, Olofsson, Tommie, Soliymani, Rabah, Baumann, Marc, Wirths, Oliver, Bayer, Thomas A, Nilsson, Lars NG, Basun, Hans, Lannfelt, Lars, Ingelsson, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226306/
https://ncbi.nlm.nih.gov/pubmed/24252272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-60
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