Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease: A NOVEL TOOL FOR THERAPY AND DIAGNOSIS

N-terminally truncated Aβ peptides starting with pyroglutamate (AβpE3) represent a major fraction of all Aβ peptides in the brain of Alzheimer disease (AD) patients. AβpE3 has a higher aggregation propensity and stability and shows increased toxicity compared with full-length Aβ. In the present work...

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Detalhes bibliográficos
Main Authors: Wirths, Oliver, Erck, Christian, Martens, Henrik, Harmeier, Anja, Geumann, Constanze, Jawhar, Sadim, Kumar, Sathish, Multhaup, Gerd, Walter, Jochen, Ingelsson, Martin, Degerman-Gunnarsson, Malin, Kalimo, Hannu, Huitinga, Inge, Lannfelt, Lars, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009878/
https://ncbi.nlm.nih.gov/pubmed/20971852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178707
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