The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

BACKGROUND: The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here we report the special character of Arctic AD neuropathology in four deceased pat...

詳細記述

保存先:
書誌詳細
出版年:Acta Neuropathol Commun
主要な著者: Kalimo, Hannu, Lalowski, Maciej, Bogdanovic, Nenad, Philipson, Ola, Bird, Thomas D, Nochlin, David, Schellenberg, Gerard D, Brundin, RoseMarie, Olofsson, Tommie, Soliymani, Rabah, Baumann, Marc, Wirths, Oliver, Bayer, Thomas A, Nilsson, Lars NG, Basun, Hans, Lannfelt, Lars, Ingelsson, Martin
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2013
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226306/
https://ncbi.nlm.nih.gov/pubmed/24252272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-60
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