Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

The roles of Argonaute proteins in cytoplasmic microRNA and RNAi pathways are well established. However, their implication in small RNA-mediated transcriptional gene silencing in the mammalian cell nucleus is less understood. We have recently shown that intronic siRNAs cause chromatin modifications...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Alló, Mariano, Agirre, Eneritz, Bessonov, Sergey, Bertucci, Paola, Gómez Acuña, Luciana, Buggiano, Valeria, Bellora, Nicolás, Singh, Babita, Petrillo, Ezequiel, Blaustein, Matías, Miñana, Belén, Dujardin, Gwendal, Pozzi, Berta, Pelisch, Federico, Bechara, Elías, Agafonov, Dmitry E., Srebrow, Anabella, Lührmann, Reinhard, Valcárcel, Juan, Eyras, Eduardo, Kornblihtt, Alberto R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226100/
https://ncbi.nlm.nih.gov/pubmed/25313066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416858111
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