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DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation

Heterogeneous nuclear ribonucleoprotein (hnRNP) K is a nucleocytoplasmic shuttling protein that is a key player in the p53-triggered DNA damage response, acting as a cofactor for p53 in response to DNA damage. hnRNP K is a substrate of the ubiquitin E3 ligase MDM2 and, upon DNA damage, is de-ubiquit...

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Detalhes bibliográficos
Main Authors: Pelisch, Federico, Pozzi, Berta, Risso, Guillermo, Muñoz, Manuel Javier, Srebrow, Anabella
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436322/
https://ncbi.nlm.nih.gov/pubmed/22825850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390120
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