Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid disposition within DILIsym®, a mechanistic model of DILI...

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Vydáno v:Front Pharmacol
Hlavní autoři: Woodhead, Jeffrey L., Yang, Kyunghee, Siler, Scott Q., Watkins, Paul B., Brouwer, Kim L. R., Barton, Hugh A., Howell, Brett A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224072/
https://ncbi.nlm.nih.gov/pubmed/25426072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00240
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