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A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation
Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU)...
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| Veröffentlicht in: | PLoS Genet |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4222680/ https://ncbi.nlm.nih.gov/pubmed/25375110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004753 |
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