The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation

Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of the replication fork. The rs5745906 SNP of the NEIL1 gene is a rare human germline variant that encodes the NEIL1 G83D protein, which is devoid...

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Publicado en:Oncotarget
Autores principales: Galick, Heather A., Marsden, Carolyn G., Kathe, Scott, Dragon, Julie A., Volk, Lindsay, Nemec, Antonia A., Wallace, Susan S., Prakash, Aishwarya, Doublié, Sylvie, Sweasy, Joann B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689654/
https://ncbi.nlm.nih.gov/pubmed/29156764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20716
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