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The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation
Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of the replication fork. The rs5745906 SNP of the NEIL1 gene is a rare human germline variant that encodes the NEIL1 G83D protein, which is devoid...
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| Yayımlandı: | Oncotarget |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Impact Journals LLC
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5689654/ https://ncbi.nlm.nih.gov/pubmed/29156764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20716 |
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