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Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase

The base excision repair (BER) pathway repairs oxidized lesions in the DNA that result from reactive oxygen species generated in cells. If left unrepaired, these damaged DNA bases can disrupt cellular processes such as replication. NEIL1 is one of the 11 human DNA glycosylases that catalyze the firs...

Полное описание

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Prakash, Aishwarya, Moharana, Kedar, Wallace, Susan S., Doublié, Sylvie
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389659/
https://ncbi.nlm.nih.gov/pubmed/27994037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1282
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