A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation

Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU)...

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Publicat a:PLoS Genet
Autors principals: Sjolund, Ashley, Nemec, Antonia A., Paquet, Nicolas, Prakash, Aishwarya, Sung, Patrick, Doublié, Sylvie, Sweasy, Joann B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222680/
https://ncbi.nlm.nih.gov/pubmed/25375110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004753
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