A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation

Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact. DNA Polymerase β (Pol β), encoded by the POLB gene, is the main gap-filling polymerase involved in base excision repair (BER), a pathway tha...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamtich, Jennifer, Nemec, Antonia A., Keh, Agnes, Sweasy, Joann B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493456/
https://ncbi.nlm.nih.gov/pubmed/23144635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003052
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