Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia: Clinical Facts and Fiction

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy are poorly understood, but the benefits of several years of myelosuppressive maintenance therapy for acute lymphoblastic leukemia are well proven. Currently, there is no international consensus on drug d...

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Detalles Bibliográficos
Publicado en:J Pediatr Hematol Oncol
Main Authors: Schmiegelow, Kjeld, Nielsen, Stine N., Frandsen, Thomas L., Nersting, Jacob
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2014
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222610/
https://ncbi.nlm.nih.gov/pubmed/24936744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0000000000000206
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