Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia: Clinical Facts and Fiction

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy are poorly understood, but the benefits of several years of myelosuppressive maintenance therapy for acute lymphoblastic leukemia are well proven. Currently, there is no international consensus on drug d...

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Detalles Bibliográficos
Publicado en:J Pediatr Hematol Oncol
Autores principales: Schmiegelow, Kjeld, Nielsen, Stine N., Frandsen, Thomas L., Nersting, Jacob
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222610/
https://ncbi.nlm.nih.gov/pubmed/24936744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0000000000000206
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