Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Among 1614 children with acute lymphoblastic leukemia (ALL) treated with the Nordic Society for Paediatric Haematology and Oncology (NOPHO) ALL-92 protocol, 20 patients developed a second malignant neoplasm (SMN) with a cumulative risk of 1.6% at 12 years from the diagnosis of ALL. Nine of the 16 ac...

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Detalhes bibliográficos
Main Authors: Schmiegelow, Kjeld, Al-Modhwahi, Ibrahim, Andersen, Mette Klarskov, Behrendtz, Mikael, Forestier, Erik, Hasle, Henrik, Heyman, Mats, Kristinsson, Jon, Nersting, Jacob, Nygaard, Randi, Svendsen, Anne Louise, Vettenranta, Kim, Weinshilboum, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699230/
https://ncbi.nlm.nih.gov/pubmed/19224761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-187880
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