Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

BACKGROUND: Methotrexate (MTX) eradicates leukemic cells by disrupting de novo nucleotide biosynthesis and DNA replication, resulting in cell death. Since its introduction in 1947, MTX-containing chemotherapeutic regimens have proven instrumental in achieving curative effects in acute lymphoblastic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Hematol Oncol
Prif Awduron: Wojtuszkiewicz, Anna, Peters, Godefridus J., van Woerden, Nicole L., Dubbelman, Boas, Escherich, Gabriele, Schmiegelow, Kjeld, Sonneveld, Edwin, Pieters, Rob, van de Ven, Peter M., Jansen, Gerrit, Assaraf, Yehuda G., Kaspers, Gertjan J. L., Cloos, Jacqueline
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455979/
https://ncbi.nlm.nih.gov/pubmed/26022503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0158-9
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg