Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

BACKGROUND: Methotrexate (MTX) eradicates leukemic cells by disrupting de novo nucleotide biosynthesis and DNA replication, resulting in cell death. Since its introduction in 1947, MTX-containing chemotherapeutic regimens have proven instrumental in achieving curative effects in acute lymphoblastic...

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Detalles Bibliográficos
Publicado en:J Hematol Oncol
Main Authors: Wojtuszkiewicz, Anna, Peters, Godefridus J., van Woerden, Nicole L., Dubbelman, Boas, Escherich, Gabriele, Schmiegelow, Kjeld, Sonneveld, Edwin, Pieters, Rob, van de Ven, Peter M., Jansen, Gerrit, Assaraf, Yehuda G., Kaspers, Gertjan J. L., Cloos, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455979/
https://ncbi.nlm.nih.gov/pubmed/26022503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0158-9
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