Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis

OBJECTIVES: An efficient pharmacological response to MTX treatment in RA patients relies on the retention and accumulation of intracellular MTX-polyglutamates catalysed by the enzyme folylpolyglutamate synthetase (FPGS). We recently identified a partial retention of FPGS intron 8 (8PR) as a prominen...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Muller, Ittai B, Lin, Marry, Lems, Willem F, ter Wee, Marieke M, Wojtuszkiewicz, Anna, Nurmohamed, Michael T, Cloos, Jacqueline, Assaraf, Yehuda G, Jansen, Gerrit, de Jonge, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937028/
https://ncbi.nlm.nih.gov/pubmed/32940699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa428
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